The film grossed over US$250,000,000 worldwide ($111,549,836 domestically).
Although the story is set in both Washington D.C. and Baltimore, most of the filming was done in Baltimore.
Mel Gibson and Tom Cruise were considered for the part that went to Will Smith, who took the role largely because he wanted to work with Gene Hackman and had previously enjoyed working with producer Jerry Bruckheimer on Bad Boys.
George Clooney was also considered for a role in the film. Sean Connery was considered for the role that went to Hackman. The film's crew included a technical surveillance counter-measures consultant who also had a minor role as a spy shop merchant.
Enemy of the State was generally well-received by critics. Rotten Tomatoes presented a 70% "Fresh" rating for the movie, with 57 critics approving of the movie and 24 noting the film as "Rotten;" similar results could be found at the website Metacritic, which displayed a normalized ranking of 67 out of 100 on the basis of the views of 22 critics. Kenneth Turan of the Los Angeles Times expressed enjoyment in the movie, noting how the movie's "pizazz [overcame] occasional lapses in moment-to-moment plausibility;" Janet Maslin of the New York Times approved of the film's action-packed sequences, but cited how it was similar in manner to the rest of the members of "Simpson's and Bruckheimer's school of empty but sensation-packed filming." In a combination of the two's views, Edvins Beitiks of the San Francisco Examiner praised many of the movies' development aspects, but criticized the overall concept that drove the movie from the beginning — the efficiency of government intelligence — as unrealistic.
The film opened at #2, behind The Rugrats Movie, grossing $20,038,573 over its first weekend in 2,393 theaters and averaging about $8,374 per venue.